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Polymorphisms of UGT1A7 and XRCC1 are Associated with Risk of Hepatocellular Carcinoma

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all—p c fc p l me a e c a n r a to AS— l e s e ii oy r s h i e ci n( e PCR)a d PCR—e tito r g n e g h p l mo p im ( n r srci n fa me tln t o y r h s RFL,a d P) n f rwh c h d sr t OR wih 9% c n i e c n ev l 9 o ih t eo d ai o( t 5 o fd n eit r a ( 5% CI )weec lu ae . r ac l td R e u t:Th r p ri n o s ls e p o o to f UGT1 o e z mai lee r2 o 3 A7 l w n y t all r

)wa i h ri c sh g e n HCC ai ns t a h s n p te t h n to e i c n r l .T e UGTl /2 a d/ 3 g n t p s we e a s c a e t i h r HCC i k ( o to s h A7 1 n 3 e o y e r s o i t d wi h g e h r s 0R=2 0,9% CI . O 3 9 .9 5:1 1一 . 7:

OR= 6,9%CI .6 l .0 e p ci e y .Th 5.7 5:17一 3,r s e tv l ) 8 eXRCC1 c d n 3 9 Ar/ n g n t p o l lo ee ae HCC rs o o 9 g Gl e o y e c u d a s l v t ik ( OR=2 1, 5 CI12— . ) I d iin t oy r h s so .6 9% .9 361 . n a d to o p l mo p im fUGT1 n A7 a d XRCCl,mutvait o itcr g e so li rael g si e r si n a a y i e n l s sd mo sr t d t a t e i n fc n n e e de t a t r s o i t d wih HCC r n t a e h to h r sg ii a ti d p n n c o sa s c a e t f we e HBV i f c i n r n e to 0R=6 . 7 80 .

9%CI 80— 6 .6,HCV n e to ( 5:2 .3 1 52 ) i f ci n OR=3 .7 5 09,9%CI:8.6 1 89 ) a d f mi itr o 0— .4 n a l h so y f HCC ( 1 y OR=1 .2 06, 9%CI 2.2 5 .7 . 5: 2— 07 ) Co c uso n l i n:Th t d h ws t a he p l m o p im s of UGT1 n e su y s o h tt oy r hs A7 a d XRCC1 r s o i t d wih HCC rs . a e a s c a e t i k D e e m i i o he pol or hi m s GT 1 7 a XR CC 1 ay p ovi a m p t ntcl o pr ven i ea ur t r naton f t ym p s of U A nd m r de n i or a ue t e tve m s e a i tH C C. ga ns

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Polymorphisms of UGT1A7 and XRCC1 are Associated with Risk of Hepatocellular Carcinoma

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