KY02111_1118807-13-8_DataSheet_MedChemExpress

抑制剂 拮抗剂 激动剂 化合物库 天然产物 中间体 药物杂质

Product Data Sheet KY02111 1118807-13-8 HY-13815 376.86 C18H17ClN2O3S >98% Product Name: CAS No.: Cat. No.: MWt: Formula: Purity : Solubility: DMSO 75 mg/ml; water <1 mg/ml Mechanisms: Pathways:Wnt/Hedgehog/Notch; Target:Wnt Biological Activity: KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes. IC50 value: Target: Wnt signaling inhibitor KY02111 Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors. KY02111 (10 μM) increases the ratio of beating cardiac colonies as much as 70%-94% in cell aggregates of two hESC lines (KhES-1 and KhES-3), four hiPSC lines (253G1, IMR90-1, IMR90-4, and RCHIPC0003), and a mouse ESC line (R1). KY02111 (10 μM) results in 73%-85% postive IMR90-1 hiPSCs expressing the cardiac markers, cardiac troponin T (cTnT), αActinin, or NKX2.5, whereas only a few DMSO-treated cells are positive for the markers. KY02111 (10 μM) results in 16% postive IMR90-1 hiPSCs expressing the cardiac pacemaker marker, HCN4, whereas the ratio of Vimentin-positive cells (fibroblasts) d... References: [1]. Minami I, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60. Caution: Not fully tested. For research purposes only Medchemexpress LLC http://doc.xuehai.net m o c . s s e r p x e m e h c d e m . w w w : b e AW Sm Uo ,c 0 4. 5s 8s 0e r p Jx Ne ,m n e oh t c e cd ne i rm P @ ,o y f an Wi : l ni oa sm n iE k l i W 8 1

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