Astrogenesis versus astrogliosis
Andrew O. Koob*
【期刊名称】中国神经再生研究(英文版)
【年(卷),期】2017(012)002
【总页数】2
In the mammalian cortex, certain astrocyte subtypes can serve as local adult progenitors. This process of local astrogenesis has been linked to astrogliosis, a nebulous term to describe the astrocytic response to injury and disease. The current evidence indicates that astrogliosis occurs in a context-specif i c manner along a graded continuum in response to injury: from subtle perturbations to severe insult to the parenchyma (Sofroniew, 2015). Since astrocytes can proliferate locally during astrogliosis in the cortex, this has important implications on the effect of nervous system communication due to astrocytic communicative contacts with other cell types and the vasculature. Also, while a subset of astrocytes undergoing astrogliotic processes have been shown to proliferate, some evidence demonstrates localized astrogenesis can occur in the cortex independent of a response to injury and disease.
During development, fate-mapping studies have shown that local astrocyte expansion in the cortex occurs 3 weeks postnatally in the rodent brain (~6–8 fold). after cell migration from the germinal layers
我要评论