学海网 文档下载 文档下载导航
设为首页 | 加入收藏
搜索 请输入内容:  
 导航当前位置: 文档下载 > 所有分类 > Astrogenesisversus astrogliosis

Astrogenesisversus astrogliosis

Astrogenesis versus astrogliosis

Andrew O. Koob*

【期刊名称】中国神经再生研究(英文版)

【年(卷),期】2017(012)002

【总页数】2

In the mammalian cortex, certain astrocyte subtypes can serve as local adult progenitors. This process of local astrogenesis has been linked to astrogliosis, a nebulous term to describe the astrocytic response to injury and disease. The current evidence indicates that astrogliosis occurs in a context-specif i c manner along a graded continuum in response to injury: from subtle perturbations to severe insult to the parenchyma (Sofroniew, 2015). Since astrocytes can proliferate locally during astrogliosis in the cortex, this has important implications on the effect of nervous system communication due to astrocytic communicative contacts with other cell types and the vasculature. Also, while a subset of astrocytes undergoing astrogliotic processes have been shown to proliferate, some evidence demonstrates localized astrogenesis can occur in the cortex independent of a response to injury and disease.

During development, fate-mapping studies have shown that local astrocyte expansion in the cortex occurs 3 weeks postnatally in the rodent brain (~6–8 fold). after cell migration from the germinal layers

第1页

TOP相关主题

我要评论

相关文档

    站点地图 | 文档上传 | 侵权投诉 | 手机版
    新浪认证  诚信网站  绿色网站  可信网站   非经营性网站备案
    本站所有资源均来自互联网,本站只负责收集和整理,均不承担任何法律责任,如有侵权等其它行为请联系我们.
    文档下载 Copyright 2013 doc.xuehai.net All Rights Reserved.  email
    返回顶部