化痰通络法改善颈动脉粥样硬化患者血管内皮功能研究_王志强

辽宁中医药大学学报

第11卷 第8期 2009 年 8 月

辽宁中医药大学学报

JOURNAL OF LIAONING UNIVERSITY OF TCM

Vol. 11 No. 8 Aug . ，2009

化痰通络法改善颈动脉粥样硬化患者血管内皮功能研究

王志强，张学平，张怀印，张 伟

（魏县中医院内科，河北 魏县 056800）

目的：采用随机非盲平行对照的研究方法,探讨颈动脉粥样硬化患者服用中药化痰通络汤3个月后血摘 要：

管内皮功能的改善。方法：80例颈动脉粥样硬化患者被随机分为治疗组和对照组。治疗组加用中药化痰通络汤浓煎液每次50mL,每日2次,维持3个月。以高分辨率超声测定的肱动脉血流介导内皮依赖性舒张功能(FMD)作为血管内皮功能的评估指标。分别在治疗前、治疗3个月时对FMD及血一氧化氮(NO)、一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)、内皮素(ET)等血管内皮功能相关因子进行检测。结果：① 治疗3个月时两组FMD均有明显改善(P<0.05),但中药化痰通络汤组FMD明显高于对照组(P<0.05);② 经治疗, 中药化痰通络汤组NO、NOS、SOD、ET均改善(P<0.05)。结论：在常规治疗基础上,颈动脉粥样硬化患者长期服用中药化痰通络汤可进一步改善血管内皮功能。

颈动脉粥样硬化；血管内皮功能；中医药疗法关键词：

(2009) R543.5 文献标识码：B 文章编号：1673-842X 08- 0105- 02中图分类号：Improvement of Huatan Tongluo Method on Vascular Endothelial

Function in Neck Atherosclerosis Patients

WANG Zhi-qiang,ZHANG Xue-ping,ZHANG Huai-yin,ZHANG Wei

（Weixian Chinese Medical Hospital Medicine,Weixian 056800,Hebei,China）

Objective: Adopt a random and non-blind research method contrasting of equal rank, Abstract：

discuss the neck atherosclerosis patient taking the traditional Chinese medicine-rization sputum exchanging functional improvement of net-like things soup After 3 months treatment. Methods:80 examples neck atherosclerosises patient is devided to cur group and contrast group mark by the random. The soup curing a group adding the traditional Chinese medicine-rization sputum of use exchange net-like things is dense fry liquid at every time 50mL, are 2 times per day, maintain 3 months. The upper arm arterial blood stream surpassing the sound admeasurement with high resolution is situated between leading the Neipi dependence relaxation function (FMD) being the blood vessel bast function's appraising an index. The nitric oxide (NO) , the nitric oxide close blood vessel bast function relevances such as enzyme (NOS) , superoxide dismutase (SOD) , bast vegetable (ET) respectively when curing front , after curing 3 months give a test for FMD and blood factor . Two set of FMD have equally improving.Results:(1) cures 3 months P<0.05), but the traditional Chinese medicine-rization sputum exchanges obvious net-like things soup group FMD group higher than collation (P<0.05); (2) classics cures , the traditional Chinese medicine-rization sputum exchanges net-like things soup group NO , NOS , SOD , ET to improve (Pequally <0.05). Conclusion:The neck atherosclerosis patient long times takes the traditional Chinese medicine-rization sputum exchanging net-like things Tang which can improve the blood vessel bast function further有良好的降压和肾功能保护作用，但是，仍有部分患者因出现不良反应而停止联合治疗，对这样的病例有必要寻找其他肾脏保护药物。

滋肾清肝丸能够显著降低尿微量白蛋白排泄，具有良好的肾功能保护作用。临床治疗结果表明，治疗组与对照组相比在降压方面并无优势，治疗组总有效率70.6％，对照组总有效率85.3％（P<0.05）；但在降低尿微量蛋白上优势明显，治疗组治疗前尿蛋白为（119.8±58.4）mg/L，治疗后为（27.1±14.8）mg/L，差异具有显著性（P<0.05），同时显示，与对照组治疗后相比尿蛋白排泄量亦明显减少，治疗组治疗后（27.1±14.8）mg/L，对照组治疗后（48.6±25.4）mg/L,差异具有显著性（P<0.05），表明滋肾清肝丸的降低尿微量蛋白作用优于贝那普利。综合以上结果表明，滋肾清肝丸能够显著降低尿微量蛋白，保护肾功能。是否三类药物联合应用能够发挥更好的降压及肾功能保护作用，有待于进一步的临床研究证实。◆

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2009-03-08收稿日期：

河北省中医药管理局指令性课题（2008039）基金项目：

王志强（1972-），男，河北魏县人，副主任中医师，学士，研究方向：心血管、脑血管疾病。作者简介：

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